A simple yet surprising clinical observation on Overactive Bladder Overactive bladder is caused by an abnormal entry of calcium ions into the bladder smooth muscle cells through pathways other than physiological ones. The increase in intracellular calcium triggers microcontractions that increase bladder tone, facilitate the opening of the first sphincter, and can lead to urinary leakage. Sensory afferents to the spinal cord and brain amplify signals from the bladder, generating pain, urgency, and incontinence, the latter resulting from incoordination. Under normal conditions, however, only a painless sense of fullness is perceived. beta blocker reduces adrenergic hyperactivity secondary to stress, decreases the release of norepinephrine and ATP, and raises the contraction threshold of the detrusor muscle. I have successfully used atenolol 25 mg/day on myself, as a sufferer of overactive bladder, and on five other patients, achieving complete remission of symptoms in all cases.
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You’re not imagining it — persistent facial pressure is often neurological, not sinus-related. This misconception leads countless patients down the wrong treatment path. Emerging research and clinical insights show that: • Trigeminal nerve sensitization can mimic sinus pain • Cervical spine dysfunction frequently refers pressure to the face • Many cases diagnosed as “sinus headaches” are actually neurologically driven Understanding this distinction matters — for diagnosis, for patient care, and for reducing unnecessary medications or procedures. If your patients report chronic pressure that doesn’t respond to decongestants or antibiotics, consider a neurological source.
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🔬 One of the Silent Risks Hiding Behind “Normal” Lab Results Did you know that some of the patients with early liver disease have normal liver enzymes? In clinical practice, we often reassure patients based on AST and ALT alone — but emerging evidence shows this may give a false sense of security. Key Insight: Subclinical liver fibrosis can progress quietly. Reliance on liver enzymes alone misses the bigger picture: fibrosis can be present even when AST and ALT are within normal range. What clinicians should consider: 👉 Use of non-invasive fibrosis scores (FIB-4, NAFLD score) 👉 Early use of transient elastography in at-risk patients (diabetics, metabolic syndrome, obesity) 👉 Lifestyle intervention before biochemical derangement appears Takeaway: Normal lab values do not guarantee normal organ function. In modern medicine, we must move from reactive treatment to predictive detection. Question for colleagues: ➡️ Are we ready to integrate fibrosis risk scoring as a standard screening tool in primary care? What barriers do you see in your practice?
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Electric Nerve Stimulation: A New Hope for Treating Chronic Constipation A new preclinical study shows that precise electrical stimulation of the sacral nerves, the nerves responsible for controlling bowel movements, can successfully restore normal colon activity. Researchers used short, gentle electrical pulses to activate these nerves, helping rats with severe constipation regain healthy intestinal motion. This technique works by mimicking the body’s natural nerve-signaling rhythm, triggering digestion without the need for medication. Scientists believe it may become a promising, non-drug therapy for patients whose chronic constipation does not respond well to standard treatments. The next step is to test this method in human clinical trials to confirm safety and effectiveness. If successful, sacral nerve stimulation could offer a new pathway to improve digestive health, reduce symptoms, and enhance overall energy and metabolic balance. For complete information and to collect points, follow our instagram & X @miraba.health or Toronto Health Hub.
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Mona Taha, Certified Diabetes Educator, joins Dr. Hammad Hussain and Dr. Rabih Hijazi, Staff Physicians in Endocrinology at the Medical Specialty Institute, to discuss the future of diabetes care and how technology is transforming the way we manage the disease. From early screening and precision medicine to AI models that predict and prevent complications, they share how innovation and the right support can help patients thrive. Watch the full episode via https://lnkd.in/dWhHjADT
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Clinical Breakthrough in Natural Neuropathy Management: The ALA-B12 Synergy New research reveals a powerful synergistic relationship between two well-studied compounds that could transform how we approach peripheral neuropathy. The Science: 👉 Alpha Lipoic Acid (600-1200mg daily) reduces oxidative stress markers by up to 71% 👉 Methylcobalamin B12 (active form) supports myelin sheath repair 👉 Together, they address both the inflammatory cause and structural damage of neuropathy Clinical Evidence: The SYDNEY 2 trial demonstrated 69.5% pain reduction using ALA, while multiple studies show methylcobalamin improves nerve conduction velocity. The combination appears to create effects greater than either compound alone. Practical Application: For healthcare professionals and patients, this represents an evidence-based natural approach that complements conventional treatments. The key is using the proper forms and dosages with realistic expectations (8-12 week timeline). I've analyzed the complete protocol, including: 👉 Optimal dosing strategies 👉 Form selection criteria 👉 Expected outcomes timeline 👉 Integration with conventional care Full analysis for medical professionals and informed patients: https://lnkd.in/e67ZydSZ #HealthcareInnovation #Neuropathy #FunctionalMedicine #MedicalResearch #IntegrativeMedicine
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Thrilled to share my first academic publication and research project titled “Impact of Structured Medication Therapy Management on Type 2 Diabetes Mellitus and Hypertension as Associated Co-Morbidity” in the International Journal of Advancement in Life Sciences Research. This work explores how structured medication therapy management through pharmacological adjustments, lifestyle modifications, and patient education can significantly improve blood pressure, glycemic control, and patient outcomes in T2DM and hypertension. Grateful to my mentors and co-authors for their constant support and guidance throughout this journey. DOI link: https://lnkd.in/dMbSgtaS
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Clinical experience of a fetal postmortem imaging service using microfocus computed tomography - Axial and coronal micro-CT of renal abnormalities A and B, Axial micro-CT of renal abnormalities. C and D, Coronal micro-CT of renal abnormalities. This case at 14 weeks of gestation was diagnosed antenatally with malrotated kidneys (closed white arrow), with the isthmus of a horseshoe kidney (closed white arrow) demonstrated on micro-CT. https://ow.ly/AqXS50XmZ95
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👨⚕️ A 45-year-old patient complained of constant, burning pain on the dorsum of the foot. 🦶 This localization suggested superficial peroneal nerve neuropathy. Unfortunately, no morphological changes were found along the course of the nerve. 💉 We performed a diagnostic block in the standard location, above the lateral malleolus. This provided complete, but temporary, relief. Based on this, we proceeded with pulsed radiofrequency and ordered an electromyography. 🎓 The “correct” academic approach would have been to start with EMG. However, in practice, this would have delayed the procedure by several months. We decided instead to begin therapy first. ⚖️ With hundreds of patients monthly, it is a constant struggle to balance between the optimal, academic pathway and the need for fast relief. In our experience, every month of delay in treating neuropathic pain reduces the chance of recovery. That is why we often initiate treatment before completing the full diagnostic process. 💭 We would appreciate your opinion on this approach.
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https://zurl.co/rpWNM Across HEMOTION, TRAIN and SAHaRA, liberal transfusion thresholds (haemoglobin triggers 9–10 g/dL) performed as well as or better than restrictive strategies (7–8 g/dL) in acute brain injury. Trials reported lower rates of unfavourable neurological outcomes and fewer cerebral ischaemic events or vasospasm with liberal strategies, challenging the belief that restrictive practice is safe for this population.
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Clinical experience of a fetal postmortem imaging service using microfocus computed tomography - Axial and coronal micro-CT of renal abnormalities A and B, Axial micro-CT of renal abnormalities. C and D, Coronal micro-CT of renal abnormalities. This case at 14 weeks of gestation was diagnosed antenatally with malrotated kidneys (closed white arrow), with the isthmus of a horseshoe kidney (closed white arrow) demonstrated on micro-CT. https://ow.ly/24Pv50XrCuv
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It's fascinating how breakthroughs in understanding biochemical pathways can lead to effective treatments. Sharing insights like this can truly inspire further exploration.