giuseppe frontera’s Post

A simple yet surprising clinical observation on Overactive Bladder Overactive bladder is caused by an abnormal entry of calcium ions into the bladder smooth muscle cells through pathways other than physiological ones. The increase in intracellular calcium triggers microcontractions that increase bladder tone, facilitate the opening of the first sphincter, and can lead to urinary leakage. Sensory afferents to the spinal cord and brain amplify signals from the bladder, generating pain, urgency, and incontinence, the latter resulting from incoordination. Under normal conditions, however, only a painless sense of fullness is perceived. beta blocker reduces adrenergic hyperactivity secondary to stress, decreases the release of norepinephrine and ATP, and raises the contraction threshold of the detrusor muscle. I have successfully used atenolol 25 mg/day on myself, as a sufferer of overactive bladder, and on five other patients, achieving complete remission of symptoms in all cases.

It's fascinating how breakthroughs in understanding biochemical pathways can lead to effective treatments. Sharing insights like this can truly inspire further exploration.

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